Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer.
10.1016/j.apsb.2021.05.006
- Author:
Ying LIU
1
;
Zan SONG
1
;
Yajie LIU
1
;
Xubin MA
1
;
Wang WANG
1
;
Yu KE
1
;
Yichao XU
1
;
Dequan YU
2
;
Hongmin LIU
1
Author Information
1. State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Henan Key Laboratory of Drug Quality Control & Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Ministry of Education of China, Zhengzhou 450001, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
5-FU, 5-fluorouracil;
Autophagy;
CDX, cell line-derived xenograft;
DCFH-DA, dichlorodihydro-fluorescein diacetate;
DCM, dichloromethane;
Ferroptosis;
Ferrous iron;
GPX4;
Gastric cancer;
IKE, imidazole ketone erastin;
JDA derivative;
JDA, Jiyuan oridonin A;
Jiyuan Rabdosia rubescens;
KEGG, Kyoto Encyclopedia of Genes and Genomes;
NAC, N-acetylcysteine;
PARP, poly ADP-ribose polymerase;
PDX, patient-derived tumor xenograft;
PK, pharmacokinetic;
Papp, apparent permeability coefficient;
ROS;
ROS, reactive oxygen species;
RTV, relative tumor volume;
Verp, verapamil;
qRT-PCR, quantitative real time PCR
- From:
Acta Pharmaceutica Sinica B
2021;11(6):1513-1525
- CountryChina
- Language:English
-
Abstract:
Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation, thus stimulating ferroptosis may be a potential strategy for treating gastric cancer, therapeutic agents against which are urgently required. Jiyuan oridonin A (JDA) is a natural compound isolated from Jiyuan
