Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses.
10.1016/j.apsb.2020.12.014
- Author:
Qian HU
1
;
Christopher J LYON
2
;
Jesse K FLETCHER
2
;
Wenfu TANG
1
;
Meihua WAN
1
;
Tony Y HU
2
Author Information
1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
2. Center of Cellular and Molecular Diagnosis, Tulane University School of Medicine, New Orleans, LA 70112, USA.
- Publication Type:Review
- Keywords:
ADSCs, adipose-derived stem cells;
AKI, acute kidney injury;
ALI, acute lung injury;
AMs, alveolar macrophages;
BMSCs, bone marrow stromal cells;
CLP, cecal ligation and puncture;
DSS, dextran sodium sulphate;
EVs, extracellular vesicles;
Extracellular vesicles;
HSPA12B, heat shock protein A12B;
HUCMSCs, human umbilical cord mesenchymal stem cells;
IBD, inflammatory bowel disease;
ICAM-1, intercellular adhesion molecule 1;
IL-1β, interleukin-1β;
Inflammatory disease;
Interaction loop;
KCs, Kupffer cells;
KLF4, krüppel-like factor 4;
LPS, lipopolysaccharides;
MHC, major histocompatibility complex;
MSCs, mesenchymal stromal cells;
MVs, microvesicles;
Macrophage;
PEG, polyethylene glycol;
PMFA, 5,7,30,40,50-pentamethoxyflavanone;
PPARγ, peroxisome proliferator-activated receptor γ;
SIRPα, signal regulatory protein α;
Sepsis;
Stem cell;
TECs, tubular epithelial cells;
TNF, tumor necrosis factor;
TRAIL, tumor necrosis factor-related apoptosis-inducing ligand;
Targeted therapy;
Tissue injury;
iNOS, inducible nitrogen oxide synthase
- From:
Acta Pharmaceutica Sinica B
2021;11(6):1493-1512
- CountryChina
- Language:English
-
Abstract:
Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation, injury, and repair processes. Recent studies indicate that tissue cells and macrophages interact
