A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine.

Haiyu XU; Yanqiong Zhang; Ping Wang; Junhong Zhang; Hong Chen; Luoqi Zhang; Xia DU; Chunhui Zhao; Dan WU; Feng Liu; Hongjun Yang; Changxiao Liu

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A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine.

Author: Haiyu XU ¹ ; Yanqiong ZHANG ¹ ; Ping WANG ¹ ; Junhong ZHANG ¹ ; Hong CHEN ¹ ; Luoqi ZHANG ¹ ; Xia DU ¹ ; Chunhui ZHAO ¹ ; Dan WU ¹ ; Feng LIU ² ; Hongjun YANG ¹ ; Changxiao LIU ³
Author Information

1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. Shaanxi Institute of International Trade & Commerce, Xianyang 7120462, China.
3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Publication Type:Review
Keywords: Big data; Integrative pharmacology-based traditional Chinese medicine; Mathematical modeling; Multidimensional association network; PK–PD correlations
From: Acta Pharmaceutica Sinica B 2021;11(6):1379-1399
CountryChina
Language:English
Abstract: Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics (PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes