Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang.
10.1016/S1875-5364(21)60101-2
- Author:
Jin-Jin ZHANG
1
,
2
;
Bao-Song CHEN
1
,
2
;
Huan-Qin DAI
1
,
2
;
Jin-Wei REN
3
;
Li-Wei ZHOU
3
;
Sheng-Hua WU
4
;
Hong-Wei LIU
1
,
5
Author Information
1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2. Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China.
3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
4. Department of Biology, National Museum of Natural Science, Taichung 40453, Taiwan, China. Electronic address: shwu@mail.nmns.edu.tw.
5. Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: liuhw@im.ac.cn.
- Publication Type:Journal Article
- Keywords:
Anti-coronavirus activity;
Cellular antioxidant activity;
Glucose-uptake stimulation;
Polyphenols;
Sanghuangporus sanghuang;
Sesquiterpenoids
- MeSH:
Agaricales;
Antioxidants/pharmacology*;
Basidiomycota;
COVID-19/drug therapy*;
Glucose;
Humans;
Molecular Docking Simulation;
Polyphenols/pharmacology*;
SARS-CoV-2;
Sesquiterpenes/pharmacology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(9):693-699
- CountryChina
- Language:English
-
Abstract:
A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identification of fourteen secondary metabolites (1-14) including eight sesquiterpenoids (1-8) and six polyphenols (9-14). Compounds 1-3 were sesquiterpenes with new structures which were elucidated based on NMR spectroscopy, high resolution mass spectrometry (HRMS) and electronic circular dichroism (ECD) data. All the isolates were tested for their stimulation effects on glucose uptake in insulin-resistant HepG2 cells, and cellular antioxidant activity. Compounds 9-12 were subjected to molecular docking experiment to primarily evaluate their anti-coronavirus (SARS-CoV-2) activity. As a result, compounds 9-12 were found to increase the glucose uptake of insulin-resistant HepG2 cells by 18.1%, 62.7%, 33.7% and 21.4% at the dose of 50 μmol·L
