New tirucallane-type triterpenoids from the resin of Boswellia carteriiand their NO inhibitory activities.
10.1016/S1875-5364(21)60099-7
- Author:
Fang-Shen LIU
1
,
2
;
Ting-Ting ZHANG
1
,
2
;
Jun XU
1
,
2
;
Qin-Xue JING
1
,
2
;
Chi GONG
1
,
2
;
Bang-Jian DONG
3
;
Da-Hong LI
1
,
2
;
Xiao-Qiu LIU
4
;
Zhan-Lin LI
1
,
2
;
Zhong YUAN
5
;
Hui-Ming HUA
1
,
6
Author Information
1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
5. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: yuanzhong@syphu.edu.cn.
6. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: huimhua@163.com.
- Publication Type:Journal Article
- Keywords:
Boswellia carterii Birdw.;
NO inhibition;
seco-Tirucallane triterpenoids
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(9):686-692
- CountryChina
- Language:English
-
Abstract:
Six new tirucallane-type triterpenoids (1-6), along with ten known triterpenoids, were isolated from methylene chloride extract of the resin of Boswellia carterii Birdw. By the application of the comprehensive spectroscopic data, the structures of the compounds were clarified. The experimental electronic circular dichroism spectra were compared with those calculated, which allowed to assign the absolute configurations. Compounds 5 and 6 possesed a 2, 3-seco tirucallane-type triterpenoid skeleton, which were first reported. Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated. Compound 9 showed appreciable inhibitory effect, with an IC
