Lignans with (N, N-diethyl)methyl amino group from Buxus rugulosa.
10.1016/S1875-5364(21)60064-X
- Author:
Yu-Huan WANG
1
;
Yong YIN
1
;
Le-Tian CUI
1
;
Qiu-Rong LI
1
;
Ling-Yi KONG
2
;
Jun LUO
3
Author Information
1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
3. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojun@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
(N, N-diethyl)methyl amino group;
Buxus rugulosa;
Lignan glycoside
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(9):675-679
- CountryChina
- Language:English
-
Abstract:
Buxrugulosides A-E, four lignan glycosides (1-4) and a protocatechuate derivative (5) featuring a rare (N, N-diethyl)methyl amino group at aromatic rings, were obtained from the aerial parts of Buxus rugulosa, which is famous for treating coronary heart disease. Their structures including absolute configurations were elucidated by HRMS, 1D and 2D NMR, and by comparing their CD data with previous reports. Compound 1 was a rare sesquilignan, and all of these compounds were the first example of lignans with (N, N-diethyl)methyl amino group.
