A review: biosynthesis of plant-derived labdane-related diterpenoids.
10.1016/S1875-5364(21)60100-0
- Author:
Ke GAO
1
;
Wen-Long ZHA
1
;
Jian-Xun ZHU
1
;
Cheng ZHENG
2
;
Jia-Chen ZI
3
Author Information
1. College of Pharmacy, Jinan University, Guangzhou 510632, China.
2. Zhejiang Institute for Food and Drug Control, NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine, Hangzhou 310052, China. Electronic address: joeff30@163.com.
3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: zijiachen@imm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Biosynthesis;
Cytochrome P450 enzyme;
Diterpene synthase;
Labdane-related diterpenoids
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(9):666-674
- CountryChina
- Language:English
-
Abstract:
Plant-derived labdane-related diterpenoids (LRDs) represent a large group of terpenoids. LRDs possess either a labdane-type bicyclic core structure or more complex ring systems derived from labdane-type skeletons, such as abietane, pimarane, kaurane, etc. Due to their various pharmaceutical activities and unique properties, many of LRDs have been widely used in pharmaceutical, food and perfume industries. Biosynthesis of various LRDs has been extensively studied, leading to characterization of a large number of new biosynthetic enzymes. The biosynthetic pathways of important LRDs and the relevant enzymes (especially diterpene synthases and cytochrome P450 enzymes) were summarized in this review.
