New bisabolane-type phenolic sesquiterpenoids from the marine sponge Plakortis simplex.
10.1016/S1875-5364(21)60062-6
- Author:
Jie WANG
1
,
2
;
Li LIU
3
;
Li-Li HONG
3
;
Kai-Xuan ZHAN
4
;
Zheng-Jiang LIN
5
;
Wei-Hua JIAO
6
;
Hou-Wen LIN
7
Author Information
1. School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China
2. Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
3. Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
4. Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.
5. School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China.
6. Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: weihuajiao@hotmail.com.
7. Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: franklin67@126.com.
- Publication Type:Journal Article
- Keywords:
Marine sponge;
Plakordiols;
Plakortis simplex;
Sesquiterpene phenols
- MeSH:
Animals;
Anti-Bacterial Agents/pharmacology*;
China;
Molecular Structure;
Monocyclic Sesquiterpenes/pharmacology*;
Pacific Ocean;
Plakortis/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(8):626-631
- CountryChina
- Language:English
-
Abstract:
Six new bisabolane-type phenolic sesquiterpenoids, including plakordiols A-D (1-4), (7R, 10R)-hydroxycurcudiol (5) and (7R, 10S)-hydroxycurcudiol (6) were isolated from the marine sponge Plakortis simplex collected from the South China Sea. Their structures were determined based on extensive analysis of spectroscopic data. Their configurations were assigned by coupling constant analysis, NOESY correlations, and the modified Mosher's method. Furthermore, their cytotoxic and antibacterial activities were evaluated.
