Three new coumarins and a new coumarin glycoside from Micromelum integerrimum.
10.1016/S1875-5364(21)60061-4
- Author:
Nan-Kai CAO
1
;
Yue-Mei CHEN
1
;
Si-Si ZHU
1
;
Ke-Wu ZENG
1
;
Ming-Bo ZHAO
1
;
Jun LI
1
;
Peng-Fei TU
1
;
Yong JIANG
2
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: yongjiang@bjmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Coumarin glycoside;
Coumarins;
ECD;
Micromelum integerrimum;
Rutaceae
- MeSH:
Coumarins/isolation & purification*;
Glycosides/isolation & purification*;
Molecular Structure;
Plant Leaves/chemistry*;
Plant Stems/chemistry*;
Rutaceae/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(8):621-625
- CountryChina
- Language:English
-
Abstract:
Three new coumarins, integmarins A-C (1-3), and a new coumarin glycoside, integmaside A (4) were isolated from the leaves and stems of Micromelum integerrimum. Their structures were elucidated on the basis of 1D and 2D NMR and MS data, and their absolute configurations were assigned according to the ECD data of the in situ formed transition metal complexes and comparison of experimental and calculated ECD data. Compounds 1 and 2 are two rare coumarins with butyl and propyl moieties at the C-6 position; compound 3 is a novel coumarin with a highly oxidized prenyl group, and compound 4 is a rare bisdihydrofuranocoumarin glycoside.
