Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity.
10.1016/S1875-5364(21)60052-3
- Author:
Chen YAN
1
,
2
;
Qun LONG
3
,
4
;
Yun-Dong ZHANG
5
;
Gajendran BABU
3
,
4
;
Madhu Varier KRISHNAPRIYA
6
;
Jian-Fei QIU
3
,
4
;
Jing-Rui SONG
3
,
4
;
Qing RAO
3
,
4
;
Ping YI
3
,
4
;
Mao SUN
1
,
7
;
Yan-Mei LI
3
,
8
Author Information
1. Department of Pharmacy, An Shun City People's Hospital, Anshun 561000, China
2. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China. Electronic address: nazi3647@sina.com.
3. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China
4. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
5. Department of Pharmacy, An Shun City People's Hospital, Anshun 561000, China.
6. Department of Medical Biochemistry, Dr. ALM PGIBMS, University of Madras, Taramani Campus, Chennai, India.
7. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China. Electronic address: sunmaohaohao@163.com.
8. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China. Electronic address: liyanmei518@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Anti-leukemia;
Carpesium cernuum;
Germacranolides;
K562;
MAPK
- MeSH:
Antineoplastic Agents, Phytogenic/pharmacology*;
Asteraceae/chemistry*;
Drug Screening Assays, Antitumor;
Humans;
K562 Cells;
Phytochemicals/pharmacology*;
Sesquiterpenes, Germacrane/pharmacology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(7):528-535
- CountryChina
- Language:English
-
Abstract:
In this study, three new germacranolide sesquiterpenes (1-3), together with six related known analogues (4-9) were isolated from the whole plant of Carpesium cernuum. Their structures were established by a combination of extensive NMR spectroscopic analysis, HR-ESIMS data, and ECD calculations. The anti-leukemia activities of all compounds towards three cell lines (HEL, KG-1a, and K562) were evaluated in vitro. Compounds 1-3 exhibited moderate cytotoxicity with IC
