Lignans with NO inhibitory activity from Tinospora sinensis.
10.1016/S1875-5364(21)60049-3
- Author:
Jun-Sheng ZHANG
1
;
De-Feng XU
2
;
Xin-Xin CAO
2
;
Yin-Yin WANG
2
;
Hua ZHANG
3
Author Information
1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: 021872104120@ujn.edu.cn.
2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
3. School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
- Publication Type:Journal Article
- Keywords:
ECD calculation;
Lignan glucoside;
NO inhibition;
Oxyneolignan;
Tinospora sinensis
- MeSH:
Animals;
Glucosides/pharmacology*;
Lignans/pharmacology*;
Lipopolysaccharides;
Mice;
Molecular Structure;
Nitric Oxide;
Phytochemicals/pharmacology*;
RAW 264.7 Cells;
Tinospora/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(7):500-504
- CountryChina
- Language:English
-
Abstract:
Two new lignan glucosides, tinsinlignans A and B (1 and 2), two new oxyneolignans, tinsinlignans C and D (3 and 4), along with one known analogue (5), were isolated from the stems of Tinospora sinensis. The structures of the new compounds were elucidated based on analysis of spectroscopic data, and the absolute configuration of 1 was determined through electronic circular dichroism (ECD) calculation based on the time-dependent density functional theory (TD-DFT). Compounds 1-4 were evaluated for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells and compounds 1 and 2 exhibited moderate inhibitory activities with IC
