New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba.
10.1016/S1875-5364(21)60048-1
- Author:
Van-Tuan VU
1
;
Xiao-Juan XU
1
;
Kang CHEN
1
;
Manh-Tuyen NGUYEN
2
;
Bich-Ngoc NGUYEN
2
;
Giang-Nam PHAM
3
;
Ling-Yi KONG
4
;
Jian-Guang LUO
5
Author Information
1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. Department of Traditional Medicine, Hanoi University of Pharmacy, Hanoi, Vietnam.
3. College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
4. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
5. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojg@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Magnolia officinalis;
NO inhibitory activity;
Oligomeric neolignans
- MeSH:
Animals;
Lignans/pharmacology*;
Magnolia/chemistry*;
Mice;
Molecular Structure;
Phytochemicals/pharmacology*;
Plant Extracts/pharmacology*;
Plant Leaves/chemistry*;
RAW 264.7 Cells
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(7):491-499
- CountryChina
- Language:English
-
Abstract:
Six new oligomeric neolignans including two trimeric neolignans (1 and 2) and four dimeric neolignans (3-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined based on HR-ESIMS and NMR data, as well as electronic circular dichroism (ECD) calculations. Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety, which is an unprecedented type of linkage between monomers. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1 and 3 showed significantly inhibitory activities with IC
