An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline (alkaloids) from Stephania tetrandra roots.
10.1016/j.joim.2021.01.001
- Author:
Eric Wei Chiang CHAN
1
;
Siu Kuin WONG
2
;
Hung Tuck CHAN
3
Author Information
1. Faculty of Applied Sciences, UCSI University, Kuala Lumpur 56000, Malaysia. Electronic address: chanwc@ucsiuniversity.edu.my.
2. School of Foundation Studies, Xiamen University Malaysia, Selangor 43900, Malaysia.
3. Secretariat of the International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan.
- Publication Type:Review
- Keywords:
Alkaloids;
Anticancer;
Fangchinoline;
Multi-drug resistance;
Pharmacology;
Tetrandrine
- MeSH:
Alkaloids/pharmacology*;
Benzylisoquinolines/pharmacology*;
Stephania tetrandra
- From:
Journal of Integrative Medicine
2021;19(4):311-316
- CountryChina
- Language:English
-
Abstract:
Tetrandrine (TET) and fangchinoline (FAN) are dominant bisbenzylisoquinoline (BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linked by oxygen bridges. The molecular structures of TET and FAN are exactly the same, except that TET has a methoxy (-OCH
