Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD) and non-CCVD patients.
10.1007/s11684-020-0825-2
- Author:
Yu WANG
1
;
Lan LI
1
;
Yuanjiang PAN
2
;
Yu HE
3
;
Zuhua CHEN
4
;
Yunhao XUN
4
;
Yuhan XU
1
;
Yilei GUO
1
;
Jiehong YANG
5
;
Jianchun GUO
6
;
Haitong WAN
7
Author Information
1. Institute of Cardio-cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
2. Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
3. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
4. Integrated TCM & Western Medicine Department, Xixi Hospital of Hangzhou, Hangzhou, 310023, China.
5. School of Basic Medical Sciences and Public Health, Zhejiang Chinese Medical University, Hangzhou, 310053, China. yjhong@zcmu.edu.cn.
6. Integrated TCM & Western Medicine Department, Xixi Hospital of Hangzhou, Hangzhou, 310023, China. guojianchun1961@126.com.
7. Institute of Cardio-cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou, 310053, China. haitongw@163.com.
- Publication Type:Journal Article
- Keywords:
COVID-19;
cardio-cerebrovascular disease;
clinical features;
clinical therapeutics;
traditional Chinese medicine
- MeSH:
COVID-19;
Cerebrovascular Disorders/epidemiology*;
Comorbidity;
Humans;
SARS-CoV-2;
Tomography, X-Ray Computed
- From:
Frontiers of Medicine
2021;15(4):629-637
- CountryChina
- Language:English
-
Abstract:
Cardio-cerebrovascular disease (CCVD) is a major comorbidity of Coronavirus disease 2019 (COVID-19). However, the clinical characteristics and outcomes remain unclear. In this study, 102 cases of COVID-19 from January 22, 2020 to March 26, 2020 in Xixi Hospital of Hangzhou were included. Twenty cases had pre-existing CCVD. Results showed that compared with non-CCVD patients, those with CCVD are more likely to develop severe disease (15% versus 1%), and the proportion of pneumonia severity index grade IV was significantly higher (25% versus 3.6%). Computed tomography images demonstrated that the proportion of multiple lobe lesion involvement was significantly higher in the CCVD group than in the non-CCVD group (90% versus 63.4%). Compared with non-CCVD group, the levels of C-reactive protein, fibrinogen, D-dimer, and serum amyloid-A were higher, whereas the total protein and arterial partial PaO
