Targeting "undruggable" c-Myc protein by synthetic lethality.
10.1007/s11684-020-0780-y
- Author:
Chen WANG
1
;
Hui FANG
2
;
Jiawei ZHANG
3
;
Ying GU
4
Author Information
1. Division of Genome Medicine and Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
2. Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, 310058, China.
3. Division of Genome Medicine and Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. jwzhang@zju.edu.cn.
4. Division of Genome Medicine and Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. guyinghz@zju.edu.cn.
- Publication Type:Review
- Keywords:
c-Myc;
synthetic lethality;
transcription factor;
undruggable
- MeSH:
Humans;
Mutation;
Neoplasms/genetics*;
Proteins;
Proto-Oncogene Proteins c-myc/genetics*;
Synthetic Lethal Mutations
- From:
Frontiers of Medicine
2021;15(4):541-550
- CountryChina
- Language:English
-
Abstract:
Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting "undruggable" proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related to c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny but not for normal cells. We further discuss strategies to identify these functional nodes in the context of synthetic lethality. We review the progress and shortcomings of this research field and look forward to opportunities offered by synthetic lethal screening to treat tumors potently.
