Proteins moonlighting in tumor metabolism and epigenetics.
10.1007/s11684-020-0818-1
- Author:
Lei LV
1
;
Qunying LEI
2
,
3
,
4
,
5
Author Information
1. MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. lvlei@fudan.edu.cn.
2. Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences
3. Cancer Institutes
4. Key Laboratory of Breast Cancer in Shanghai
5. The Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University, Shanghai, 200032, China. qlei@fudan.edu.cn.
- Publication Type:Review
- Keywords:
epigenetics;
moonlighting function;
tumor metabolism
- MeSH:
Energy Metabolism;
Epigenesis, Genetic;
Humans;
Metabolic Networks and Pathways;
Neoplasms/genetics*;
Tumor Microenvironment
- From:
Frontiers of Medicine
2021;15(3):383-403
- CountryChina
- Language:English
-
Abstract:
Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells. To respond to nutrient stress and to meet the requirements for rapid cell proliferation, cancer cells reprogram metabolic pathways to take up more glucose and coordinate the production of energy and intermediates for biosynthesis. Such actions involve gene expression and activity regulation by the moonlighting function of oncoproteins and metabolic enzymes. The signal - moonlighting protein - metabolism axis facilitates the adaptation of tumor cells under varying environment conditions and can be therapeutically targeted for cancer treatment.
