Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos.
10.1007/s13238-021-00824-z
- Author:
Yu WEI
1
;
Yingsi ZHOU
1
;
Yajing LIU
1
;
Wenqin YING
1
;
Ruiming LV
1
;
Qimeng ZHAO
1
;
Haibo ZHOU
1
;
Erwei ZUO
2
;
Yidi SUN
3
;
Hui YANG
4
;
Changyang ZHOU
5
Author Information
1. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
2. Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China. erweizuo@163.com.
3. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. sydaileen@gmail.com.
4. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. huiyang@ion.ac.cn.
5. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. zhouchangyang@ion.ac.cn.
- Publication Type:Letter
- From:
Protein & Cell
2021;12(9):741-745
- CountryChina
- Language:English
