Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2.

Dan Zhao; Weifan XU; Xiaofan Zhang; Xiaoting Wang; Yiyue GE; Enming Yuan; Yuanpeng Xiong; Shenyang WU; Shuya LI; Nian WU; Tingzhong Tian; Xiaolong Feng; Hantao Shu; Peng Lang; Jingxin LI; Fengcai Zhu; Xiaokun Shen; Haitao LI; Pilong LI; Jianyang Zeng

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Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2.

Author: Dan ZHAO ¹ ; Weifan XU ² ; Xiaofan ZHANG ¹ ; Xiaoting WANG ³ ; Yiyue GE ⁴ ; Enming YUAN ¹ ; Yuanpeng XIONG ⁵ ; Shenyang WU ⁶ ; Shuya LI ¹ ; Nian WU ¹ ; Tingzhong TIAN ¹ ; Xiaolong FENG ⁷ ; Hantao SHU ¹ ; Peng LANG ¹ ; Jingxin LI ⁴ ; Fengcai ZHU ⁴ ; Xiaokun SHEN ⁸ ; Haitao LI ⁹ ; Pilong LI ¹⁰ ; Jianyang ZENG ¹¹
Author Information

1. Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, 100084, China.
2. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
3. Silexon AI Technology Co., Ltd, Nanjing, 210033, China.
4. NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, 210009, China.
5. Bioinformatics Division, BNRIST/Department of Computer Science and Technology, Tsinghua University, Beijing, 100084, China.
6. Protein Preparation and Identification Facility, Technology Center for Protein Science, Tsinghua University, Beijing, 100084, China.
7. Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
8. Convalife (Shanghai) Co., Ltd, Shanghai, 201203, China.
9. Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
10. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084, China. pilongli@mail.tsinghua.edu.cn.
11. Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, 100084, China. zengjy321@tsinghua.edu.cn.
Publication Type:Comment
MeSH: COVID-19; Coronavirus Nucleocapsid Proteins; Humans; Nucleocapsid Proteins; Phosphoproteins; SARS-CoV-2
From: Protein & Cell 2021;12(9):734-740
CountryChina
Language:English