Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma.

Xiaochen Wang; Kang LI; Yuehan Wan; Fangfang Chen; Maosheng Cheng; Gan Xiong; Ganping Wang; Shuang Chen; Zhi Chen; Jianwen Chen; Xiuyun XU; Cheng Wang; Liang Peng; Demeng Chen

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Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma.

Author: Xiaochen WANG ¹ ; Kang LI ¹ ; Yuehan WAN ² ; Fangfang CHEN ¹ ; Maosheng CHENG ¹ ; Gan XIONG ² ; Ganping WANG ¹ ; Shuang CHEN ¹ ; Zhi CHEN ¹ ; Jianwen CHEN ¹ ; Xiuyun XU ² ; Cheng WANG ³ ; Liang PENG ⁴ ; Demeng CHEN ⁵
Author Information

1. Center for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
2. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
3. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China. wangch75@mail.sysu.edu.cn.
4. Oncology Department, Chinese PLA General Hospital, Beijing, China. pengliang_301@163.com.
5. Center for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. chendm29@mail.sysu.edu.cn.
Publication Type:Research Support, Non-U.S. Gov't
MeSH: Head and Neck Neoplasms; Humans; Squamous Cell Carcinoma of Head and Neck/genetics*
From: International Journal of Oral Science 2021;13(1):26-26
CountryChina
Language:English
Abstract: Methyltransferase like 13 (METTL13), a kind of methyltransferase, is implicated in protein binding and synthesis. The upregulation of METTL13 has been reported in a variety of tumors. However, little was known about its potential function in head and neck squamous cell carcinoma (HNSCC) so far. In this study, we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level. Increased METTL13 was negatively associated with clinical prognosis. And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro. Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail, the key transcription factor in EMT, hence regulating the progression of EMT. Furthermore, Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes. Altogether, our study had revealed the oncogenic role of METTL13 in HNSCC, and provided a potential therapeutic strategy.