Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer.

Wenwen Zhong; Dejuan Wang; Bing Yao; Xiaoxia Chen; Zhongyang Wang; Hu QU; Bo MA; Lei YE; Jianguang Qiu

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Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer.

Author: Wenwen ZHONG ¹ ; Dejuan WANG ¹ ; Bing YAO ¹ ; Xiaoxia CHEN ² ; Zhongyang WANG ¹ ; Hu QU ¹ ; Bo MA ¹ ; Lei YE ¹ ; Jianguang QIU ³
Author Information

1. Department of Urology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
2. Department of Medical Record Management Section, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
3. Department of Urology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China. qiujg@mail.sysu.edu.cn.
Publication Type:Journal Article
Keywords: Bladder cancer; Copy number variation (CNV); Long non-coding RNA (lncRNA); Prognosis
From: Journal of Zhejiang University. Science. B 2021;22(8):664-681
CountryChina
Language:English
Abstract: Copy number variations (CNVs), which can affect the role of long non-coding RNAs (lncRNAs), are important genetic changes seen in some malignant tumors. We analyzed lncRNAs with CNV to explore the relationship between lncRNAs and prognosis in bladder cancer (BLCA). Messenger RNA (mRNA) expression levels, DNA methylation, and DNA copy number data of 408 BLCA patients were subjected to integrative bioinformatics analysis. Cluster analysis was performed to obtain different subtypes and differently expressed lncRNAs and coding genes. Weighted gene co-expression network analysis (WGCNA) was performed to identify the co-expression gene and lncRNA modules. CNV-associated lncRNA data and their influence on cancer prognosis were assessed with Kaplan-Meier survival curve. Multi-omics integration analysis revealed five prognostic lncRNAs with CNV, namely