Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response.

Author: Yuhua LIU ¹ ; Xiaopeng WAN ² ; Yuan YUAN ³ ; Jingjing HUANG ² ; Yijia JIANG ² ; Kaiyue ZHAO ⁴ ; Yan WANG ³ ; Yang LIU ² ; Qingqing WANG ² ; Hongchuan JIN ¹
Author Information

1. Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310016, China.
2. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
3. Department of Clinical Laboratory, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
4. Department of Radiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Publication Type:Journal Article
Keywords: Endotoxin tolerance; MicroRNA-155 (miR-155); Suppressor of cytokine signaling 1 (SOCS1); Toll-like receptor 4 (TLR4); Transforming growth factor-β-activated kinase 1-binding protein 2 (TAB2)
From: Journal of Zhejiang University. Science. B 2021;22(7):590-598
CountryChina
Language:English
Abstract: Although microRNA-155 (miR-155) is considered a pro-inflammatory mediator, cumulative evidence indicates that it also has anti-inflammatory effects in macrophages and dendritic cells. In this study, we identified the dramatic expression changes of more than half of potential miR-155-targeted genes upon lipopolysaccharide (LPS) stimulation; 223 genes were down-regulated and 85 genes were up-regulated, including suppressor of cytokine signaling 1 (