Opposite Modulatory Effects of Crataegus aronia Aqueous Extract on Platelet Aggregation in Rats.
10.1007/s11655-020-3187-3
- Author:
Abdullah S SHATOOR
1
;
Ali SHATI
2
;
S Al HUMAYED
3
;
Sultan AL-QAHTANI
4
;
Mahmoud ALKHATEEB
4
Author Information
1. Department of Medicine, Cardiology Section, College of Medicine, King Khalid University, Abha, 64121, Saudi Arabia. asshalghamdi@yahoo.com.
2. Department of Biology, College of Science, College of Medicine, King Khalid University, Abha, 64121, Saudi Arabia.
3. Department of Medicine, Cardiology Section, College of Medicine, King Khalid University, Abha, 64121, Saudi Arabia.
4. Department of Physiology, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 11481, Saudi Arabia.
- Publication Type:Journal Article
- Keywords:
Crataegus aronia;
Intracellular cyclic adenosine monophosphate;
P2Y12;
aggregation;
nuclear factor αB;
platelets;
reactive oxygen species
- From:
Chinese journal of integrative medicine
2021;27(9):696-704
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To reveal the mechanisms behind the dual effects of Crataegus aronia (C. aronia) aqueous extract on platelet aggregation by focusing on function, regulation, expression, and signaling of platelets P
METHODS:Adult male Wistar rats (120 ± 10 g) were classified as control received the vehicle, C. aronia (200 mg/kg), and C. aronia (2,000 mg/kg)-treated rats. After treatments for consecutive 7 days, hematological and molecular experiments were conducted to detect alterations in platelet aggregation, thromboxane B2 (THXB2) and intracellular reactive oxygen species (ROS) content; protein levels of P
RESULTS:At a concentration of 200 mg/kg, C. aronia inhibited platelet aggregation through multiple interconnected mechanisms including downregulation P
CONCLUSION:Oral administration of C. aronia at low dose inhibits platelet aggregation by reducing THXB2 release, expression of P-selectin and activating cAMP and Akt signaling through two major mechanisms including downregulation of P
