Correlation between estimated plasma remnant-like particle cholesterol and vegetable fat intake in Uku town, Japan.
10.1186/s12199-021-01005-4
- Author:
Hisashi ADACHI
1
;
Tatsuyuki KAKUMA
2
;
Mika ENOMOTO
3
;
Ako FUKAMI
3
;
Sachiko NAKAMURA
3
;
Yume NOHARA
3
;
Nagisa MORIKAWA
3
;
Akiko SAKAUE
3
;
Maki YAMAMOTO
3
;
Yoshihiro FUKUMOTO
3
Author Information
1. Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of Medicine, Kurume, 830-0011, Japan. hadac@med.kurume-u.ac.jp.
2. Biostatistics Center, School of Medicine, Kurume University, Kurume, Japan.
3. Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of Medicine, Kurume, 830-0011, Japan.
- Publication Type:Journal Article
- Keywords:
Epidemiology;
Lipid profile;
Lipoproteins;
Remnant-like particle cholesterol;
Vegetable fat
- MeSH:
Aged;
Aged, 80 and over;
Cholesterol/blood*;
Dietary Fats/blood*;
Female;
Humans;
Japan;
Lipids/blood*;
Lipoproteins/blood*;
Male;
Middle Aged;
Triglycerides/blood*;
Vegetables
- From:Environmental Health and Preventive Medicine
2021;26(1):82-82
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Remnant-like particle cholesterol (RLP-C) is highly atherogenic, which is associated with atherosclerosis. However, RLP-C has not been routinely measured in the clinical practice. We estimated RLP-C levels using conventional lipid profiles and examined the association between estimated RLP-C and related factors including nutrient intake.
METHODS:This study was performed in Uku town, Nagasaki prefecture, Japan in 2019. A total of 225 subjects were enrolled and directly measured RLP-C levels. Estimated RLP-C levels were defined as the following formula [total cholesterol - (LDL-cholesterol) - (HDL-cholesterol)]. Multivariate analyses were used to assess the relationship between estimated RLP-C and atherogenic factors. We calculated cut-off values on dichotomized RLP-C (< 7.5 mg/dL vs. ≥ 7.5 mg/dL) by receiver operating characteristic (ROC) curve.
RESULTS:The mean values of directly measured RLP-C levels and estimated RLP-C were 4.0 mg/dL and 16.4 mg/dL, respectively. In the multiple stepwise linear regression analysis, directly measured and estimated RLP-C levels were independently and commonly associated with apolipoprotein E, triglycerides, and vegetable fat intake (inversely). Using ROC curves, we found the cut-off value of estimated RLP-C was 22.0 mg/dL.
CONCLUSION:We demonstrated that the estimated RLP-C levels using conventional lipid profiles may substitute for directly measured RLP-C and these levels were independently and inversely associated with vegetable fat intake in the community-dwelling Japanese population.
