Paradoxical effects of arsenic in the lungs.
10.1186/s12199-021-00998-2
- Author:
Caixia REN
1
;
Yang ZHOU
2
;
Wenwen LIU
2
;
Qi WANG
3
Author Information
1. Department of Respiratory Medicine, The Second Hospital of Dalian Medical University, Dalian, 116023, China.
2. Liaoning Clinical Research Center for Lung Cancer, The Second Hospital of Dalian Medical University, Dalian, 116023, China.
3. Department of Respiratory Medicine, The Second Hospital of Dalian Medical University, Dalian, 116023, China. wqdlmu@163.com.
- Publication Type:Review
- Keywords:
Arsenic;
Lung;
Pathogenic effect;
Therapeutic effect
- MeSH:
Animals;
Arsenic/toxicity*;
Dose-Response Relationship, Drug;
Humans;
Lung/pathology*;
Lung Neoplasms/drug therapy*;
Mice
- From:Environmental Health and Preventive Medicine
2021;26(1):80-80
- CountryJapan
- Language:English
-
Abstract:
High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of previous studies, we infer that low- and medium-concentration arsenic cause lung diseases in a dose-dependent manner. Arsenic trioxide (ATO) is recognized as a chemotherapeutic drug for acute promyelocytic leukemia (APL), also having a significant effect on lung cancer. The anti-lung cancer mechanisms of ATO include inhibition of proliferation, promotion of apoptosis, anti-angiogenesis, and inhibition of tumor metastasis. In this review, we summarized the role of arsenic in lung disease from both pathogenic and therapeutic perspectives. Understanding the paradoxical effects of arsenic in the lungs may provide some ideas for further research on the occurrence and treatment of lung diseases.
