Survival Analysis of 76 Cases of Head and Neck Adenoid Cystic Carcinoma
with Lung Metastasis.
10.3779/j.issn.1009-3419.2021.102.21
- Author:
Zhen YU
1
;
Lei YU
1
;
Xiaohong CHEN
2
;
Xingguo YANG
1
;
Baoxun ZHANG
1
;
Tao YU
1
;
Xin DU
1
Author Information
1. Department of Thoracic Surgery, Beijing Tongren Hospital,
Capital Medical University, Beijing 100730, China.
2. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital,
Capital Medical University, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
Adenoid cystic carcinoma;
Head and neck neoplasms;
Lung metastasis
- From:
Chinese Journal of Lung Cancer
2021;24(6):412-419
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Adenoid cystic carcinoma (ACC) of the head and neck often develops lung metastasis. At present, there are not many research reports on ACC lung metastasis, little is known about its exact clinical features and treatment results, and there is no consensus on the best treatment strategy. This study explored the effective treatment strategies, clinical outcomes and long-term prognosis of head and neck ACC lung metastases.
METHODS:The clinical and follow-up data of 76 patients with head and neck ACC lung metastases were retrospectively analyzed. According to the initial treatment of patients, they are divided into 4 groups: surgery, surgery+chemotherapy or radiotherapy, chemotherapy or radiotherapy and supportive treatment. The patients were staged according to the International Registry of Lung Metastases Staging System (IRLM). Kaplan-Meier method and Log-rank test were used to compare the statistical differences of overall survival (OS) and progression-free survival (PFS) of patients with different treatment methods and different IRLM stages.
RESULTS:The OS and PFS of patients undergoing surgery are better than those of supportive therapy or radiotherapy and/or chemotherapy (OS: P<0.000,1; PFS: P<0.000,1). The OS and PFS of patients with low stage IRLM are better than those with high stage (OS: P<0.000,1; PFS: P<0.000,1). Patients with single lung metastasis and without pleural effusion have better OS and PFS.
CONCLUSIONS:The long-term prognosis of patients with lung metastasis of head and neck ACC who undergo surgery is better than other treatments, which is related to higher OS and PFS. For patients with ACC lung metastases who are operationally eligible, the significance of complete surgical resection should be higher than other treatment options.
