Analysis of Influencing Factors for Postoperative Venous Thromboembolism
of Thymic Malignancies.
10.3779/j.issn.1009-3419.2021.101.22
- Author:
Xingguo YANG
1
;
Hui LI
2
;
Lei YU
1
;
Tao YU
1
;
Fei LI
1
;
Zhen YU
1
;
Baoxun ZHANG
1
;
Xin DU
1
Author Information
1. Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
2. Department of Thoracic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
- Publication Type:Journal Article
- Keywords:
Caprini score;
Risk factors;
Thymic malignancies;
Venous thromboembolism
- From:
Chinese Journal of Lung Cancer
2021;24(7):497-502
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The previous study has indicated that the incidence of venous thromboembolism (VTE) after thoracic surgery is high. The purpose of this study was to analyze the incidence and risk factors of postoperative VTE in thymic malignancy patients.
METHODS:This was a single-center study. Patients undergoing resection for thymic malignancy between December 2017 and February 2021 in Department of Thoracic Surgery, Beijing Tongren Hospital Affiliated to Capital Medical University were enrolled in this study. In addition to the routine examination, all patients were screened for deep venous thrombosis (DVT) by using noninvasive duplex lower extremity ultrasound before and after surgery. Patients did not receive any prophylactic anticoagulant therapy before and after surgery. All patients received modified caprini risk assessment. According to whether VTE occurred after operation, patients were divided into VTE group and control group. The clinical data of the two groups were compared. The occurrence time and possible high risk factors of VTE after operation were analyzed.
RESULTS:A total of 169 patients with thymic malignant tumor were enrolled, including 94 males and 75 females, aging from 22 to 76 years. A total of 95 patients underwent thoracoscopic surgery and 74 patients underwent median sternotomy. The total incidence of VTE was 12.4%. The median time for diagnosis of VTE was 4 days (2 days-15 days) after operation. According to the modified caprini score, the incidence of VTE in low risk patients (Caprini score≤4 points), moderate risk patients (Caprini score 5 to 8 points) and high risk patients (Caprini score≥9 points) were 0% (0/7), 7.0% (8/115) and 27.7% (13/47), respectively (Z=1.670, P=0.008). Univariate analysis showed that there were significant differences between VTE group and control group in age, operation method, operation time, indwelling central venous catheter, postoperative bed rest time more than 72 hours (P<0.05). Multivariate analysis showed that over 60 years old, operation method and operation time were independent risk factors for VTE after resection for thymic malignancies.
CONCLUSIONS:Over 60 years old, operation method and operation time are independent risk factors for VTE. Modified caprini assessment can effectively screen high-risk patients.
