Serological Identification and FUT1 Gene Mutation Analysis of 8 Individuals with Para-Bombay Phenotypes in Guangxi.
10.19746/j.cnki.issn.1009-2137.2021.04.048
- Author:
Jin-Lian LIU
1
;
Xue-Jun LIU
1
;
Ting-Ting MA
1
;
Jie-Run CHEN
1
;
Li-Lan LI
2
Author Information
1. Nan-Ning Institute of Transfusion Medicine, Nanning Blood Center, Nanning 530007, Guangxi Zhuang Autonomous Region, China.
2. Nan-Ning Institute of Transfusion Medicine, Nanning Blood Center, Nanning 530007, Guangxi Zhuang Autonomous Region, China E-mail: lililan2010@sina.com.
- Publication Type:Journal Article
- MeSH:
ABO Blood-Group System/genetics*;
Alleles;
China;
Fucosyltransferases/genetics*;
Genotype;
Humans;
Mutation;
Phenotype
- From:
Journal of Experimental Hematology
2021;29(4):1318-1324
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the serological characteristics and molecular biological basis of 8 individuals with Para-Bombay phenotypes in Guangxi area.
METHODS:Serological tests were used to identify the blood groups of red cells. Molecular biological methods, including PCR-SSP for ABO genotyping and DNA sequencing for FUT1, were used to detect the genotypes of ABO and FUT1 which determined the expression of H antigen.
RESULTS:Eight individuals in the study were all the Para-Bombay phenotypes, including 4 cases of B
CONCLUSION:There are varieties of molecular genetic mechanisms for Para-Bombay phenotypes. In this study, the FUT1 mutations that cause Para-Bombay phenotypes in Guangxi area are mainly h3, h
