Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma.
10.3724/zdxbyxb-2021-0146
- Author:
Jingyi HU
1
;
Qingqing WANG
1
;
Yang LIU
1
Author Information
1. Institute of Immunology.
- Publication Type:Review
- Keywords:
Hepatocellular carcinoma;
Mechanism;
Proteasome;
Proteasome core particle;
Proteasome regulatory particle;
Review
- MeSH:
Carcinoma, Hepatocellular;
Cell Line, Tumor;
Cell Proliferation;
Humans;
Liver Neoplasms;
Proteasome Endopeptidase Complex/metabolism*;
STAT3 Transcription Factor/metabolism*;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2021;50(3):396-402
- CountryChina
- Language:English
-
Abstract:
Proteasome is the eukaryotic organelle responsible for degradation of short-lived proteins and involved in maintaining cellular protein homeostasis. It has been reported that during the occurrence and development of hepatocellular carcinoma (HCC), the regulatory particle subunits of proteasome regulate a series of tumor-related proteins, and proliferation, survival-associated signaling molecules, including PTEN gene, P53, Bcl-2, Bcl-2 interacting mediator of cell death (Bim), cyclin-dependent kinase 4(CDK4), transforming growth factor β receptor (TGFBR), E2F1, growth factor receptor-bound protein 2 (GRB2) . Meanwhile, these subunits regulate some tumor-associated pathway protein, such as signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT), inducing their malfunction to promote the occurrence, proliferation, invasion and metastasis of HCC. The core particle subunits are more to perform the degradation of HCC-related proteins, so inhibitors targeting the core particle show a good anti-tumor effect. This review summarizes the current research progress on the regulation and mechanism of proteasome subunits in promoting the occurrence and development .
