Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus.
10.7499/j.issn.1008-8830.2103162
- Author:
Yan-Jun YI
1
;
Xiao RAN
1
;
Jing XIANG
;
Xin-Yang LI
;
Li JIANG
1
;
Heng-Sheng CHEN
1
;
Yue HU
1
Author Information
1. Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing 400136.
- Publication Type:Journal Article
- Keywords:
Gap junction blocker;
Rat;
Ripple oscillation;
Status epilepticus
- MeSH:
Animals;
Gap Junctions;
Hippocampus;
Pilocarpine;
Rats;
Seizures;
Status Epilepticus/drug therapy*
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(8):848-853
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the effect of gap junction blockers, quinine (QUIN) and carbenoxolone (CBX), on hippocampal ripple energy expression in rats with status epilepticus (SE).
METHODS:A total of 24 rats were randomly divided into four groups: model, QUIN, valproic acid (VPA), and CBX (
RESULTS:Ripple expression was observed in the hippocampal CA1, CA3, and dentate gyrus regions of normal rats. After 10 minutes of PILO injection, all groups had a gradual increase in mean ripple energy expression compared with 1 day before modeling, with the highest expression level before chloral hydrate injection in the model, VPA and CBX groups (
CONCLUSIONS:The change in ripple energy can be used as a quantitative indicator for early warning of seizures, while it cannot predict seizures in the interictal period. Gap junction blockers can reduce ripple energy during seizures.
