Expression of adipokines in children with primary nephrotic syndrome and its association with hyperlipidemia.
10.7499/j.issn.1008-8830.2104080
- Author:
Ru-Xin ZHANG
1
;
Xuan ZHANG
1
;
Bi-Li ZHANG
1
;
Zhu-Feng LIU
1
;
Shu-Xiang LIN
Author Information
1. Department of Nephrology, Tianjin Children's Hospital, Tianjin 300074, China.
- Publication Type:Journal Article
- Keywords:
Chemerin;
Child;
Hyperlipidemia;
Omentin-1;
Primary nephrotic syndrome
- MeSH:
Adipokines;
Chemokines;
Child;
Cytokines/metabolism*;
GPI-Linked Proteins/metabolism*;
Humans;
Hyperlipidemias;
Lectins/metabolism*;
Lipids;
Nephrotic Syndrome/drug therapy*;
Proteinuria
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(8):828-834
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the expression of adipokines in children with primary nephrotic syndrome (PNS) before and after treatment and its correlation with blood lipids, as well as the role of adipokines in PNS children with hyperlipidemia.
METHODS:A total of 90 children who were diagnosed with incipient PNS or recurrence of PNS after corticosteroid withdrawal for more than 6 months were enrolled as subjects. Thirty children who underwent physical examination were enrolled as the control group. Venous blood samples were collected from the children in the control group and the children with PNS before corticosteroid therapy (active stage) and after urinary protein clearance following 4 weeks of corticosteroid therapy (remission stage). ELISA was used to measure the levels of adipokines. An automatic biochemical analyzer was used to measure blood lipid levels.
RESULTS:Compared with the control group, the children with PNS had a significantly lower level of omentin-1 in both active and remission stages, and their level of omentin-1 in the active stage was significantly lower than that in the remission stage (
CONCLUSIONS:Omentin-1 may be associated with disease activity, dyslipidemia, and proteinuria in children with PNS. Blood lipid ratios may be more effective than traditional blood lipid parameters in monitoring early cardiovascular risk in children with PNS.
