Serum amyloid P component: a new biomarker for low sperm concentration?

Annika Sonesson; Johan Malm; Lars Rylander; Aleksander Giwercman; Andreas Hillarp

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Serum amyloid P component: a new biomarker for low sperm concentration?

Author: Annika SONESSON ¹ ; Johan MALM ¹ ; Lars RYLANDER ² ; Aleksander GIWERCMAN ¹ ; Andreas HILLARP ¹
Author Information

1. Department of Translational Medicine, Lund University, Malmö 20502, Sweden.
2. Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund 22381, Sweden.
Publication Type:Journal Article
Keywords: fertility; reproduction; seminal plasma; serum amyloid P component; sperm
From: Asian Journal of Andrology 2021;23(5):450-455
CountryChina
Language:English
Abstract: Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r = 0.75), sperm number (r = 0.68), semen volume (r = -0.19), progressive sperm motility (r = 0.24), and sperm immotility (r = -0.20). When the study group was dichotomized, SAP could be used to discriminate samples with a sperm concentration < or ≥5 × 10