Association of fetal cardiac structural abnormalities and chromosomal aneuploidies and copy number variations.
10.3760/cma.j.cn511374-20200609-00421
- VernacularTitle:胎儿心脏结构异常与羊水染色体非整倍体及拷贝数变异的相关性
- Author:
Ruijie HOU
1
;
Fanjing KONG
;
Shuzhen ZHAO
;
Huimin GUO
;
Shijin WANG
Author Information
1. Department of Gynecology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453100, China. 153947590@qq.com.
- Publication Type:Journal Article
- MeSH:
Aneuploidy;
Chromosome Aberrations;
DNA Copy Number Variations;
Female;
Fetus;
Humans;
Microarray Analysis;
Pregnancy;
Prenatal Diagnosis;
Ultrasonography, Prenatal
- From:
Chinese Journal of Medical Genetics
2021;38(8):795-797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association of fetal cardiac structural abnormalities with chromosomal aneuploidies and copy number variations (CNVs) in amniocytes.
METHODS:328 pregnant women were subjected to fetal ultrasonography and chromosomal microarray analysis (CMA). Based on the fetal heart structure, the subjects were divided into normal (n=273) and abnormal groups (n=55). The detection rates of chromosomal aneuploidies and CNVs were compared between the two groups. Spearman method was used to assess the association between the results and fetal cardiac structural abnormalities.
RESULTS:The detection rates for chromosomal aneuploidies and CNVs in the abnormal group were significantly higher than that in the normal group (P< 0.05), and the incidence of fetal cardiac structural abnormalities was strongly associated with chromosomal aneuploidies and CNVs (P< 0.05).
CONCLUSION:Fetal chromosomal aneuploidies and CNVs are strongly associated with cardiac structural abnormalities.
