Association of RAGE gene polymorphisms with MHR ratio and heart rate variability among patients with coronary heart disease.
10.3760/cma.j.cn511374-20200430-00318
- Author:
Jing CHENG
1
;
Xiaoguang WU
;
Yunfu YU
;
Jifeng YAN
;
Xiaohui ZHENG
;
Chuanyu GAO
Author Information
1. Department of Emergency, Heart Center of Henan People's Hospital, Zhengzhou, Henan 410105, China. chengjing56n@126.com.
- Publication Type:Journal Article
- MeSH:
Antigens, Neoplasm;
Coronary Disease/genetics*;
Gene Frequency;
Glycation End Products, Advanced;
Heart Rate;
Humans;
Mitogen-Activated Protein Kinases;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2021;38(7):681-685
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the association of polymorphisms of receptor of advanced glycation end products (RAGE) gene, monocyte to high-density lipoprotein cholesterol ratio (MHR) and variability of heart rate among patients with coronary heart disease (CHD).
METHODS:120 patients with CHD and 120 healthy individuals were respectively selected as the observation group and the control group. Allelic and genotypic differences of -429T>C, 1704G>T, 82G>S, MHR ratio and heart rate variability between the two groups and patients with different severity were analyzed. The correlation between their genotypes and MHR ratio and heart rate variability was analyzed.
RESULTS:The 82G>S polymorphism of the RAGE gene and the allelic difference between the two groups and patients with different severity were statistically significant (P< 0.05). Compared with the control group and patients with mild to moderate phenotype, monocyte, total cholesterol, triglyceride, low density lipoprotein, MHR, low frequency in the observation group and patients with severe symptoms were significantly higher, while their high density lipoprotein, standard deviation of NN intervals (SDNN), standard deviation average of NN intervals (SDANN), root mean square successive differences, percentage of differences exceeding 50ms between adjacent normal number of intervals (PMN50), high frequency (HF) were significantly lower. The gene frequencies of G-Gly-T, T-Gly-T, G-Ser-T and G-Gly-C were correlated with SDNN, SDANN, rMSSD, PMN50, HF and MHR, but negatively correlated with low frequency.
CONCLUSION:Polymorphisms of the RAGE gene in patients with coronary heart disease are associated with the MHR ratio and heart rate variability, which can be used as markers for the diagnosis and efficacy evaluation.
