Gender difference in clinical manifestations of KBG syndrome due to variants of ANKRD11 gene.
10.3760/cma.j.cn511374-20200601-00403
- Author:
Yuyao YANG
1
;
Pengqiang WEN
;
Zhe SU
;
Li WANG
;
Xiu ZHAO
Author Information
1. Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, China. su_zhe@126.com.
- Publication Type:Journal Article
- MeSH:
Abnormalities, Multiple;
Bone Diseases, Developmental;
Child;
Facies;
Female;
Humans;
Intellectual Disability;
Male;
Phenotype;
Repressor Proteins/genetics*;
Sex Characteristics;
Tooth Abnormalities
- From:
Chinese Journal of Medical Genetics
2021;38(7):663-666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore gender difference in the clinical manifestations of two children with Keishi-Bukuryo-Gan syndrome (KBGS).
METHODS:Clinical manifestations of the two children were reviewed. Genetic testing was carried out through next generation sequencing (NGS). Treatment was summarized, and the prognosis was followed up.
RESULTS:Both children showed particular appearance including megatooth, abnormal hair distribution, hands' abnormality and language development delay. NGS revealed that both children have carried pathogenic variants of the ANKRD11 gene (c.1903_1907del and c.4911delT), which resulted in shifting of amino acid sequences starting from the Lysine and Proline at positions 635 and 1638, respectively. The female patient exhibited central precocious puberty. Her height has increased by 13 cm, and sex characteristics has retracted after treatment with leuprorelin for 23 months and recombinant human growth hormone for 1 month.
CONCLUSION:Comparison of the two cases with different genders and summary of previously reported cases found that male KBGS patients have more obvious dysmorphisms such as triangular face, synophrys, ocular hypertelorism and vertebral body abnormality, with higher morbidity of epilepsy, mental retardation, autism, congenital heart disease, immune thrombocytopenia and other complications. KBGS is an autosomal dominant disease featuring more evident peculiar appearance and global development delay. Male patients often have multi-system involvement, and multidisciplinary cooperation is required for early recognition of particular features in order to improve the prognosis.
