Research progress of necroptosis on bone related diseases.
10.12200/j.issn.1003-0034.2021.07.020
- Author:
Zu-Ge YANG
1
;
Ruo-Xin WANG
1
;
Hao-Zhe REN
1
;
Feng HE
1
;
Yuan-Jun MA
1
;
Shi-Bin YU
1
Author Information
1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
- Publication Type:Journal Article
- Keywords:
Bone marrow;
Necroptosis;
Osteonecrosis;
Osteoporosis;
Osteosarcoma
- MeSH:
Apoptosis;
Necroptosis;
Protein Kinases
- From:
China Journal of Orthopaedics and Traumatology
2021;34(7):687-690
- CountryChina
- Language:Chinese
-
Abstract:
As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens, damage associated molecular patterns (DAMPs) enter into extracellular area through the ruptured cytomembrane, followed by the disordered tissue hemeostasis. In recent years, many researches showed that necroptosis playimportant roles in a few bone related diseases, such as osteoporosis, osteonecrosis, osteosarcoma, etc. Thus, we try to briefly review the researches in this field.
