Effect of Low-Dose Enalapril in Patients with Mild to Moderate Hypertension.
10.4070/kcj.1988.18.3.441
- Author:
Jong Hoa BAE
;
Hoy Jong KIM
;
Chung Whee CHOUE
;
Kwon Sam KIM
;
Myung Shick KIM
;
Jung Sang SONG
- Publication Type:Original Article
- Keywords:
Hypertension;
Enalapril
- MeSH:
Body Weight;
Enalapril*;
Humans;
Hypertension*
- From:Korean Circulation Journal
1988;18(3):441-446
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the effect on loe-dose enalapril(ACE inhibitor), we administered a single dose of 10 mg/day enalapril to 22 patients(6 mild hypertension and 16 moderate hypertension) for 12 weeks. The systolic and diastolic blood pressures of patients were declined significantly at 4th week and at 12th week(p<0.005) without significant change of rate and body weight. These data were also analyzed in terms of the percent of patients with marked, moderate and mild responses. Enalapril yielded a 72.7% response rate in marked fall and 22.7% response rate in moderate fall which revealed 95.4% of good response rate. Enalapril was tolerated and showed no significant clinical and biochemical adverse reactions. In conclusion, these results indicate that monotherapy with enalapril 10 mg in a single daily dose was effective in the management of mild to moderate uncomplicated essential hypertension and was well tolerated.
