Research progress of hydrogel combined with mesenchymal stem cells in the treatment of spinal cord injury.
10.7507/1001-5515.202005055
- Author:
Xin YUAN
1
;
Lu DING
1
;
David Y B DENG
1
Author Information
1. Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 518107, P.R.China.
- Publication Type:Review
- Keywords:
adipose derived stem cells;
hydrogel;
mesenchymal stem cells;
spinal cord injury
- MeSH:
Humans;
Hydrogels;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells;
Spinal Cord Injuries/therapy*
- From:
Journal of Biomedical Engineering
2021;38(4):805-811
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury (SCI) is a complex pathological process. Based on the encouraging results of preclinical experiments, some stem cell therapies have been translated into clinical practice. Mesenchymal stem cells (MSCs) have become one of the most important seed cells in the treatment of SCI due to their abundant sources, strong proliferation ability and low immunogenicity. However, the survival rate of MSCs transplanted to spinal cord injury is rather low, which hinders its further clinical application. In recent years, hydrogel materials have been widely used in tissue engineering because of their good biocompatibility and biodegradability. The treatment strategy of hydrogel combined with MSCs has made some progress in SCI repair. This review discusses the significance and the existing problems of MSCs in the repair of SCI. It also describes the research progress of hydrogel combined with MSCs in repairing SCI, and prospects its application in clinical research, aiming at providing reference and new ideas for future SCI treatment.
