Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury.
10.7507/1001-5515.202012050
- Author:
Xincheng DU
1
;
Jibo WANG
2
;
Wen ZHAO
2
;
Pu CHEN
2
;
Gaozhi OU
1
Author Information
1. School of Physical Education, China University of Geosciences, Wuhan 430074, P.R.China.
2. Department of Biomedical Engineering, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan 430071, P.R.China.
- Publication Type:Review
- Keywords:
brain organoid;
brain-on-a-chip;
human relevant in vitro organotypic models;
sport-related traumatic brain injury;
sports medicine;
tissue engineering
- MeSH:
Animals;
Brain Injuries;
Brain Injuries, Traumatic;
Humans
- From:
Journal of Biomedical Engineering
2021;38(4):797-804
- CountryChina
- Language:Chinese
-
Abstract:
Sports-related traumatic brain injury (srTBI) is a traumatic brain injury (TBI) caused by sports, which can result in cognitive and motor dysfunction. Currently, research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models. However, many differences exist in cell populations and inflammatory responses between these models and human pathophysiological processes. Most of the researches derived from the models can't effectively conducted translational research. Emerging three-dimensional (3D)
