Study on the intervention of platelet biological activity by ultrasound.
10.7507/1001-5515.202005036
- Author:
Taotao LIU
1
;
Fang YANG
1
Author Information
1. Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, P.R.China.
- Publication Type:Journal Article
- Keywords:
aggregation;
bioactivity;
platelet components;
platelets;
ultrasound
- MeSH:
Blood Platelets;
Humans;
Platelet Aggregation;
Thrombosis;
Ultrasonography
- From:
Journal of Biomedical Engineering
2021;38(4):709-715
- CountryChina
- Language:Chinese
-
Abstract:
Platelets are non-nucleated blood effector cells, which plays an important role in coagulation, hemostasis, and thrombosis. However, platelets are extremely susceptible to activation by external stimuli, which in turn damages the platelet's natural biological activity and affects its biological function. Platelet biological activity has become a hotspot in the field of vascular diseases. In this study, ultrasound parameters (ultrasound intensity and duration time) were used to intervene in the biological activity of platelets. The response of platelets to ultrasound energy was explored from the aspects of platelet morphology, aggregation ability and particle release (the expression of P-selectin and the number of particles). The results showed that the ultrasound intensity of 0.25 W/cm
