A review on the application of UK Biobank in neuroimaging.
10.7507/1001-5515.202012059
- Author:
Lan LIN
1
;
Min XIONG
1
;
Shuicai WU
1
Author Information
1. Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, P.R.China.
- Publication Type:Review
- Keywords:
UK Biobank;
biomedical;
brain aging;
multimodality magnetic resonance imaging;
neuroimaging
- MeSH:
Biological Specimen Banks;
Brain;
Neuroimaging;
United Kingdom
- From:
Journal of Biomedical Engineering
2021;38(3):594-601
- CountryChina
- Language:Chinese
-
Abstract:
UK Biobank (UKB) is a forward-looking epidemiological project with over 500, 000 people aged 40 to 69, whose image extension project plans to re-invite 100, 000 participants from UKB to perform multimodal brain magnetic resonance imaging. Large-scale multimodal neuroimaging combined with large amounts of phenotypic and genetic data provides great resources to conduct brain health-related research. This article provides an in-depth overview of UKB in the field of neuroimaging. Firstly, neuroimage collection and imaging-derived phenotypes are summarized. Secondly, typical studies of UKB in neuroimaging areas are introduced, which include cardiovascular risk factors, regulatory factors, brain age prediction, normality, successful and morbid brain aging, environmental and genetic factors, cognitive ability and gender. Lastly, the open challenges and future directions of UKB are discussed. This article has the potential to open up a new research field for the prevention and treatment of neurological diseases.
