The potential role of long non-coding RNA Dnm3os in the activation of cardiac fibroblasts.
10.7507/1001-5515.202102021
- Author:
Qihang KONG
1
;
Junteng ZHOU
2
;
Geer TIAN
1
;
Yue QUAN
1
;
Wenchao WU
1
;
Xiaojing LIU
1
Author Information
1. Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
- Publication Type:Journal Article
- Keywords:
cardiac fibroblast activation;
cardiac fibrosis;
long non-coding RNA Dnm3os;
transforming growth factor-β1/Smad2/3
- MeSH:
Fibroblasts;
Fibrosis;
Humans;
Myocardium/pathology*;
RNA, Long Noncoding;
Signal Transduction;
Transforming Growth Factor beta1
- From:
Journal of Biomedical Engineering
2021;38(3):574-582
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) Dnm3os plays a critical role in peritendinous fibrosis and pulmonary fibrosis, but its role in the process of cardiac fibrosis is still unclear. Therefore, we carried out study by using the myocardial fibrotic tissues obtained by thoracic aortic constriction (TAC) in an early study of our group, and the
