Reasearch on lipid metabolism of Plasmodium and antimalarial mechanism of artemisinin.
10.19540/j.cnki.cjcmm.20210610.703
- Author:
Shuo LI
1
;
Cang-Hai LI
1
;
Ting-Liang JIANG
1
Author Information
1. Research Center of Artemisinin, China Academy of Chinese Medical Sciences Beijing 100700, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Review
- Keywords:
Plasmodium;
artemisinin;
fatty acid;
lipid metabolism;
phospholipid
- MeSH:
Antimalarials/pharmacology*;
Artemisinins/therapeutic use*;
Humans;
Lipid Metabolism;
Malaria/drug therapy*;
Plasmodium
- From:
China Journal of Chinese Materia Medica
2021;46(18):4849-4864
- CountryChina
- Language:Chinese
-
Abstract:
As a unicellular organism, Plasmodium displays a panoply of lipid metabolism pathways that are seldom found together in a unicellular organism. These pathways mostly involve the Plasmodium-encoded enzymatic machinery and meet the requirements of membrane synthesis during the rapid cell growth and division throughout the life cycle. Different lipids have varied synthesis and meta-bolism pathways. For example, the major phospholipids are synthesized via CDP-diacylglycerol-dependent pathway in prokaryotes and de novo pathway in eukaryotes, and fatty acids are synthesized mainly via type Ⅱ fatty acid synthesis pathway. The available studies have demonstrated the impacts of artemisinin and its derivatives, the front-line compounds against malaria, on the lipid metabolism of Plasmodium. Therefore, this article reviewed the known lipid metabolism pathways and the effects of artemisinin and its derivatives on these pathways, aiming to deepen the understanding of lipid synthesis and metabolism in Plasmodium and provide a theoretical basis for the research on the mechanisms and drug resistance of artemisinin and other anti-malarial drugs.
