Four new lanostane triterpenoids from latex of Euphorbia resinifera.
10.19540/j.cnki.cjcmm.20210623.201
- Author:
Miao-Miao LI
1
;
Yan-Ru QI
1
;
Ya-Ping FENG
2
;
Wei LIU
3
;
Tao YUAN
1
Author Information
1. College of Life Science, Jiangxi Normal University Nanchang 330022, China.
2. College of Life Science, Jiangxi Normal University Nanchang 330022, China Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, Yili Normal University Yining 835000, China.
3. Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, Yili Normal University Yining 835000, China.
- Publication Type:Journal Article
- Keywords:
Euphorbia resinifera;
anti-inflammatory activity;
chemical constituents;
lanostane triterpenoid
- MeSH:
Euphorbia;
Latex;
Molecular Structure;
Steroids;
Triterpenes
- From:
China Journal of Chinese Materia Medica
2021;46(18):4744-4748
- CountryChina
- Language:Chinese
-
Abstract:
Four new lanostane triterpenoids, 3β-hydroxy-12α-methoxylanosta-7,9(11),24-triene(1), 3β-hydroxy-12α-methoxy-24-methylene-lanost-7,9(11)-dien(2), 3,7-dioxo-lanosta-8,24-diene(3), and 3,7-dioxo-24-methylene-lanost-8-en(4), were isolated from the latex of Euphorbia resinifera with a variety of chromatography methods. Their structures were elucidated based on spectroscopic data and/or comparison with the data reported in previous research. Compounds 1, 2, and 4 showed moderate inhibition of LPS-induced NO production by RAW264.7, with IC_(50) of 30.4, 37.5, and 28.3 μmol·L~(-1), respectively.
