Histopathologic Observations on Behcet's Syndrome.
- Author:
Kwang Soo KIM
;
Sook Ja SON
- Publication Type:Original Article
- MeSH:
Acneiform Eruptions;
Behcet Syndrome*;
Dermis;
Dust;
Edema;
Erythema;
Erythema Nodosum;
Female;
Humans;
Incidence;
Injections, Intradermal;
Intradermal Tests;
Male;
Neutrophils;
Oral Ulcer;
Ulcer;
Vasculitis
- From:Korean Journal of Dermatology
1981;19(6):853-863
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was performed to evaluate clinical manifestations in 26 patients and histopathological findings in 19 patients with Behcets syndrome. 1. Clinical findings: A. Among the 26 patients, 9 were male and 17 were female (male to female ratio was 1: l.9). The age at onset of the disease varied from 10 to 62, with a mean of 26.9. B. The incidence of the major clinical manifestations: The oral ulcers were observed in all of the 26 patients, genital ulcers in 21 patients (81%), cutaneous manifestations in 25 patients (96%) and ocular lesions in 7 patients (27%). C. Saline intradermal test was positive in 62% and PPD intradermal test in 42% 2. Histopathological findings: Fourty-one specimens were taken frorn 19 patients with Behcets syndrome; Erythema nodosum like lesions (15), edematous papules (3), acneiform eruption (1), oral ulcers (4), genital ulcers (8), saline intradermal injection sites (5) and PPD intradermal test sites (5). As a control, 4 specirnens were taken from PPD test sites of the patients with erythem nodosum. The common histopathological findings were perivascular inflammatory cell infiltration, mainly composed of neutrophils and nuclear dusts, and vasculitis of varying degree. A. Cutaneous lesions; In erythema nodosum-like lesions main pathologic foci were in the deep dermis and/or the subcutis, and moderate to severe vasculitis were observed. In edematous papules, however, main foci were in the pa,pill- ary dermis and the upper dermis, papillary dermal edema was prorninent, and vasculitis was rather mild.
