Biopharmaceutical classification and transport mechanism of 4 alkaloids in Mongolian herbal medicine Sophorae Flavescentis Radix.
10.19540/j.cnki.cjcmm.20210319.307
- Author:
Hui-Fang LI
1
;
Jin-Hua BAO
2
;
Liang TIAN
3
;
ALISA
3
;
Zheng-Qi DONG
4
;
Almaz BORJIGIDAI
5
Author Information
1. Key Laboratory of Ethnomedicine, Ministry of Education, Minzu University of China Beijing 100081, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences Beijing 100193, China College of Mongolian Medicine, Inner Mongolia University for Nationalities Tongliao 028000, China.
2. Affiliated Hospital of Inner Mongolia University for Nationalities Tongliao 028000, China.
3. Key Laboratory of Ethnomedicine, Ministry of Education, Minzu University of China Beijing 100081, China College of Mongolian Medicine, Inner Mongolia University for Nationalities Tongliao 028000, China.
4. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences Beijing 100193, China.
5. Key Laboratory of Ethnomedicine, Ministry of Education, Minzu University of China Beijing 100081, China.
- Publication Type:Journal Article
- Keywords:
Caco-2;
Chinese herbal medicine(ethnodrug);
Sophorae Flavescentis Radix;
biopharmaceutical classification system;
permeability;
solubility
- MeSH:
Alkaloids;
Biological Products;
Caco-2 Cells;
Drugs, Chinese Herbal;
Herbal Medicine;
Humans;
Sophora
- From:
China Journal of Chinese Materia Medica
2021;46(18):4721-4729
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we studied the solubility and permeability of matrine, oxymatrine, sophoridine, and oxysophocarpine, four alkaloids in the Mongolian herbal medicine Sophorae Flavescentis Radix, and evaluated the absorption mechanism with the Caco-2 cell model, so as to provide a basis for the new drug development and efficacy evaluation of Sophorae Flavescentis Radix. The results showed that all the four alkaloids had high solubility and high permeability and can be well absorbed, belonging to the class-I drugs of Biopharmaceutical Classification System(BCS). The absorption(AP→BL) and excretion(BL→AP) of matrine and oxymatrine were not affected by the concentration while the absorption depended on P-gp protein. The absorption(AP→BL) and excretion(BL→AP) of sophoridine and oxysophocarpine were positively related to the concentration and time, and the absorption process was independent from P-gp protein. The results provide scientific reference and an experimental basis for the development of Mongolian medical prescriptions containing Sophorae Flavescentis Radix.
