Research advance of pharmacological effects of astragalosides on nervous system diseases.
10.19540/j.cnki.cjcmm.20210610.704
- Author:
Nuo XU
1
;
Xiao-Jun WU
1
Author Information
1. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai Key Laboratory of Complex Prescription Shanghai 201203, China.
- Publication Type:Review
- Keywords:
astragalosides;
nervous system disease;
pharmacological effect
- MeSH:
Astragalus Plant;
Astragalus propinquus;
Drugs, Chinese Herbal;
Humans;
Nervous System Diseases;
Quality of Life;
Saponins/pharmacology*
- From:
China Journal of Chinese Materia Medica
2021;46(18):4674-4682
- CountryChina
- Language:Chinese
-
Abstract:
Astragali Radix is a traditional Chinese herbal medicine with a long history, which has the functions of tonifying Qi and promoting urination and granulation. Astragalosides are the main effective components of Astragali Radix, and more than 40 triterpenoid saponins have been obtained from Astragalus membranaceus and its related plants, mainly including astragalosides Ⅰ-Ⅷ, isoastragalosides Ⅰ, Ⅱ, and Ⅳ, acetylastragalosides, and soyasaponins. Astragalosides have a wide range of biological activities, such as immunomodulation, antioxidation, and neuroprotection. Nervous system diseases seriously affect people's quality of life, threaten human physical and mental health, and impose a burden on families and society. As natural drugs, astragalosides have good preventive and therapeutic effects on central nervous system diseases. This paper reviews the main pharmacological effects and mechanisms of astragalosides in the treatment of multiple sclerosis, Parkinson's disease, Alzheimer's disease, and cerebral ischemic stroke and proposes the research prospects and potential problems, aiming to provide reference for the clinical application and basic research of astragalosides.
