Systematic review and Meta-analysis of efficacy and safety of Toutongning Capsules in treatment of tension-type headache.
10.19540/j.cnki.cjcmm.20210520.501
- Author:
Xue-Ming FAN
1
;
Jing-Jing WEI
2
;
Yun-Ling ZHANG
3
;
Xing LIAO
4
;
Xiao LIANG
3
;
Guo-Jing FU
5
;
Xiao GONG
3
;
Wen-Jie CHEN
3
;
Jing-Ze PIAO
5
;
Yu YAN
5
;
Chun-Li GUO
3
;
Yong-Mei YAN
6
;
Jian YANG
7
Author Information
1. Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China Center for Evidence-based Chinese Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China Graduate School,Beijing University of Chinese Medicine Beijing 100029,China.
3. Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China.
4. Center for Evidence-based Chinese Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
5. Graduate School,Beijing University of Chinese Medicine Beijing 100029,China.
6. Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000,China.
7. Chongqing Traditional Chinese Medicine Hospital Chongqing 400011,China.
- Publication Type:Systematic Review
- Keywords:
Meta-analysis;
Toutongning Capsules;
efficacy;
safety;
systematic review;
tension-type headache
- MeSH:
Capsules;
Databases, Factual;
Drugs, Chinese Herbal;
Humans;
Tension-Type Headache/drug therapy*;
Treatment Outcome
- From:
China Journal of Chinese Materia Medica
2021;46(18):4623-4632
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to systematically evaluate the clinical efficacy and safety of Toutongning Capsules in the treatment of tension-type headache(TTH), so as to provide a corresponding basis for clinical treatment. Eight commonly used medical research databases and two clinical trial registration systems were retrieved with the time interval from the establishment of the database or system to November 2020. The randomized controlled trials of Toutongning Capsules in the treatment of TTH were screened out according to the pre-set criteria. The quality of the included papers was evaluated by the bias risk assessment tool in Cochrane Reviewers Handbook 6.1 and the data were statistically analyzed by RevMan v5.4 provided by Cochrane collaboration. A total of 13 studies were included and the quality of methodology was generally low. Meta-analysis showed that Toutongning Capsules assisted with western medicine therapy can effectively reduce the pain intensity(MD_(VAS)=-1.94,95%CI[-2.50,-1.38],P<0.000 01;MD_(NRS)=-0.83,95%CI[-0.86,-0.80],P<0.000 01), headache duration(SMD=-0.98,95%CI[-1.17,-0.79],P<0.000 01), headache frequency(MD=-1.01,95%CI[-1.16,-0.85],P<0.000 01), headache index(MD=-11.13,95%CI[-12.10,-10.16],P<0.000 01), anxiety and depression scale score(MD_(HAMA)=-4.02,95%CI[-6.58,-1.46],P=0.002;MD_(HAMD)=-2.67,95%CI[-4.04,-1.29],P=0.000 1), while Toutongning Capsules as monotherapy only reduced the headache score(MD=-2.24,95%CI[-2.97,-1.51],P<0.000 01). The available clinical studies demonstrate that Toutongning Capsules combined with western medicine in the treatment of TTH can improve the related outcome indicators, but the clinical safety and efficacy of Toutongning Capsules alone remain unclear. Due to the small number and low quality of the included studies, large-sample, multi-center, high-quality and strictly designed randomized controlled trials are still needed to verify the clinical efficacy in the future.
