Chemical constituents of triterpenoids from Euphorbia resinifera.
10.19540/j.cnki.cjcmm.20210621.201
- Author:
Ya-Jie LI
1
;
Teng-Fei JI
2
;
Jun ZHAO
3
;
Zheng-Yi GU
3
Author Information
1. College of Pharmacy, Xinjiang Medical University Urumqi 830011, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &Peking Union Medical College Beijing 100050, China.
3. Xinjiang Key Laboratory for Uighur Medicines,Xinjiang Institute of Materia Medica Urumqi 830004, China.
- Publication Type:Journal Article
- Keywords:
Euphorbia resinifera;
structure identification;
triterpenoid
- MeSH:
Drugs, Chinese Herbal;
Euphorbia;
Molecular Structure;
Triterpenes
- From:
China Journal of Chinese Materia Medica
2021;46(17):4433-4437
- CountryChina
- Language:Chinese
-
Abstract:
The combination of normal-phase silica gel column chromatography, octadecyl silica(ODS) column chromatography, semi-preparative high performance liquid chromatography(HPLC), etc. was employed to isolate and purify the chemical components from Euphorbia resinifera, and 7 triterpenoids were separated from the ethanol extract of the medicinal materials. Their structures were identified by various spectroscopy methods as cycloartan-1,24-diene-3-one(1), cycloartan-1,24-diene-3-ol(2), 3β-hydroxy-lanosta-8,24-diene-11-one(3), lnonotusane C(4), eupha-8,24-diene-3β-ol-7,11-dione(5), eupha-24-methylene-8-ene-3β-ol-7,11-dione(6), and eupha-8,24-diene-3β,11β-diol-7-one(7). Compounds 1 and 2 are new compounds, and compound 3 is obtained from nature for the first time.
