Pharmacodynamics and intestinal flora research on different processed products of Puerariae Lobatae Radix and Puerariae Thomsonii Radix.
10.19540/j.cnki.cjcmm.20210205.302
- Author:
Ling-Yun ZHONG
1
;
Xiao-Yan DENG
2
;
Yi HUANG
1
;
Jing-Jing LIAO
1
;
Wei-Feng ZHU
1
;
Huan YU
1
;
Shi-Cheng ZHOU
3
;
Rui-Lin CHEN
4
Author Information
1. Jiangxi University of Chinese Medicine Nanchang 330004, China.
2. Jiangxi College of Traditional Chinese Medicine Fuzhou 344000, China.
3. Jiangxi Engineering and Technology Research Center of Puerariae, Jiangxi Guanshanyue Puerariae Work Development Co., Ltd. Shangrao 334300, China.
4. Jiangxi Jiangzhong Chinese Herbal Pieces Co., Ltd. Jiujiang 332300, China.
- Publication Type:Journal Article
- Keywords:
Puerariae Lobatae Radix;
Puerariae Thomsonii Radix;
intestinal flora;
pharmacodynamics;
processing mechanism
- MeSH:
Animals;
Drugs, Chinese Herbal;
Gastrointestinal Microbiome;
Plant Roots;
Pueraria;
Rats
- From:
China Journal of Chinese Materia Medica
2021;46(17):4403-4409
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to explore the pharmacodynamic differences of Puerariae Lobatae Radix(PLR), Puerariae Thomsonii Radix(PTR) and their different processed products and the influences of these medical materials on the diversity of intestinal flora. The Sennae Folium-induced diarrhea model, streptozotocin(STZ)-induced diabetes model and L-nitro-arginine methyl ester(L-NAME)-induced hypertension model were used to compare the pharmacodynamic differences in anti-diarrhea, blood glucose reduction and blood pressure lowering among raw, roasted and vinegar-processed PLR and PTR. The effects of raw and processed PLR and PTR on intestinal flora diversity of rats were evaluated by 16 S rDNA high-throughput sequencing. The roasted PLR and PTR performed better in anti-diarrhea, especially the former. PLR and its processed products all presented the efficacy of reducing blood glucose, and the vinegar-processed PLR was the most outstanding. The raw PTR was not that effective in reducing blood glucose, whereas its efficacy was improved after roasting and vinegar processing. Both PLR and PTR were capable of lowering blood pressure to a certain extent, and PLR is superior to PTR in this aspect. Further, the vinegar-processed PLR showed the best effect. The diversity of intestinal flora was different among rats to which different products of PLR and PTR were administered. The roasted PLR led to the highest abundance of Lactobacillus, which was closely related to its best antidiarrheal effect. The highest abilities of vinegar-processed PLR to lower blood glucose and blood pressure were associated with the high abundance of Blautia and Prevotella_9. This study lays a foundation for elucidating the processing mechanisms of PLR and PTR and provides a basis for their further development and application.
