Research on anti-tumor natural product diosgenin.
10.19540/j.cnki.cjcmm.20210610.701
- Author:
Shi-Qing ZHANG
1
;
Yu-Xuan SONG
1
;
Wen-Xue ZHANG
1
;
Ming-Jun CHEN
1
;
Shu-Li MAN
1
Author Information
1. College of Biotechnology, Tianjin University of Science & Technology Tianjin 300457, China.
- Publication Type:Review
- Keywords:
anti-tumor activity;
diosgenin;
extraction method;
review;
yield
- MeSH:
Apoptosis;
Biological Products;
Cell Proliferation;
Diosgenin/pharmacology*;
Trigonella
- From:
China Journal of Chinese Materia Medica
2021;46(17):4360-4366
- CountryChina
- Language:Chinese
-
Abstract:
Diosgenin is widely distributed in many plants, such as Polygonatum sibiricum, Paris polyphylla, Dioscorea oppositifolia, Trigonella foenum-graecum, Costus speciosus, Tacca chantrieri, which has good anti-tumor activity and preferable effects on preventing atherosclerosis, protecting the heart, treating diabetes, etc. This review combed through the anti-tumor mechanisms of diosgenin encompassing lung, breast, gallbladder, liver, oral cavity, stomach, bladder, bone marrow, etc. Besides, it was discovered that diosgenin mainly exerts its effect by inhibiting tumor cell migration, suppressing tumor cell proliferation and growth, and inducing cell apoptosis. However, problems like low yield and bioavailability frequently exist in natural diosgenin. This review introduced methods such as structural modification, dosage form optimization and combination medication to improve the yield and anti-tumor activity of diosgenin. Via the summary of this paper, it is expected to provide theoretical basis for the rational exploitation and utilization of diosgenin.
